Article
Two members of the beige/CHS (BEACH) family are involved at different stages in the organization of the endocytic pathway in Dictyostelium.
Journal of cell science - 15 Feb 2002
Cornillon Sophie, Dubois Annick, Brückert Franz, Lefkir Yaya, Marchetti Anna, Benghezal Mohammed, De Lozanne Arturo, Letourneur François, Cosson Pierre
Abstract excerpt
Proteins of the Chediak-Higashi/Beige (BEACH) family have been implicated in the function of lysosomes, as well as in signal transduction, but their molecular role is still poorly understood. In Dictyostelium, at least six members of the family can be identified. Here cells with mutations in two of these genes, LVSA and LVSB, were analyzed. Interestingly both mutants exhibited defects in the organization of the...
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