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Article

Drosophila mauve mutants reveal a role of LYST homologs late in the maturation of phagosomes and autophagosomes.

Traffic (Copenhagen, Denmark) - 1 Dec 2012

Rahman Mokhlasur, Haberman Adam, Tracy Charles, Ray Sanchali, Krämer Helmut

Abstract excerpt

Chediak-Higashi syndrome (CHS) is a lethal disease caused by mutations that inactivate the lysosomal trafficking regulator protein (LYST). Patients suffer from diverse symptoms including oculocutaneous albinism, recurrent infections, neutropenia and progressive neurodegeneration. These defects have been traced back to over-sized lysosomes and lysosome-related organelles (LROs) in different cell types. Here, we...

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Source

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Identifiers

PMID: 22934826
DOI: 10.1111/tra.12005
PMCID: PMC3528838

Genes

LYST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila mauve mutants reveal a role of LYST homologs late in the maturation of phagosomes and autophagosomes.PMID 22934826Read ↗

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