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Article

Mfsd8 localizes to endocytic compartments and influences the secretion of Cln5 and cathepsin D in Dictyostelium.

Cellular signalling - 1 Jun 2020

Huber Robert J, Mathavarajah Sabateeshan, Yap Shyong Quan

Abstract excerpt

The neuronal ceroid lipofuscinoses (NCLs) are a family of neurodegenerative diseases that affect people of all ages and ethnicities, yet many of the associated genes/proteins are not well characterized. Mutations in MFSD8 (major facilitator superfamily domain-containing 8) cause an infantile form of NCL referred to as CLN7 disease. In this study, we revealed the localization and binding partners of an ortholog of...

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PMID: 32087303
DOI: 10.1016/j.cellsig.2020.109572

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