Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of mfsd8 alters the secretome during Dictyostelium aggregation.

European journal of cell biology - 1 Dec 2023

Huber Robert J, Gray Joshua, Kim William D

Abstract excerpt

Major facilitator superfamily domain-containing protein 8 (MFSD8) is a transmembrane protein that has been reported to function as a lysosomal chloride channel. In humans, homozygous mutations in MFSD8 cause a late-infantile form of neuronal ceroid lipofuscinosis (NCL) called CLN7 disease. In the social amoeba Dictyostelium discoideum, Mfsd8 localizes to cytoplasmic puncta and vesicles, and regulates conserved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dictyostelium
Share to Lysosomes
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

Share to Mutation

Source

Identifiers

PMID: 37742391
DOI: 10.1016/j.ejcb.2023.151361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of mfsd8 alters the secretome during Dictyostelium aggregation.PMID 37742391Read ↗

Mfsd8 localizes to endocytic compartments and influences the secretion of Cln5 and cathepsin D in Dictyostelium.Semantic proximity Read ↗

Loss of Cln3 impacts protein secretion in the social amoeba Dictyostelium.Semantic proximity Read ↗

The conserved cellular roles of CLN proteins: Novel insights from Dictyostelium discoideum.Semantic proximity Read ↗

Altered protein secretion in Batten disease.Semantic proximity Read ↗

Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis.Semantic proximity Read ↗

Recent Insights into NCL Protein Function Using the Model Organism Dictyostelium discoideumSemantic proximity Read ↗

CLN5 disease-causing mutations impact lysosomal biology by affecting intracellular degradation and protein trafficking.Semantic proximity Read ↗

Dictyostelium LvsB mutants model the lysosomal defects associated with Chediak-Higashi syndrome.Semantic proximity Read ↗

Dictyostelium discoideum: A Model System for Neurological DisordersSemantic proximity Read ↗

Partial genetic suppression of a loss-of-function mutant of the neuronal ceroid lipofuscinosis-associated protease TPP1 in Dictyostelium discoideum.Semantic proximity Read ↗

Aberrant Autophagy Impacts Growth and Multicellular Development in a Dictyostelium Knockout Model of CLN5 DiseaseSemantic proximity Read ↗

Loss of Cln3 function in the social amoeba Dictyostelium discoideum causes pleiotropic effects that are rescued by human CLN3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.