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Article

Rho GTPase inactivation impairs lens growth and integrity.

Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2002

Rao Vasantha, Wawrousek Eric, Tamm Ernst R, Zigler Samuel

Abstract excerpt

To elucidate the significance of Rho GTPase signaling on lens growth and structural integrity, we have selectively inactivated Rho GTPase in the ocular lens. To achieve this tissue-specific inactivation, a transgene encoding the C3-exoenzyme from Clostridium botulinum has been expressed in mice under transcriptional control of the lens-specific alphaA-crystallin promoter. C3-exoenzyme is known to selectively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11850536
DOI: 10.1038/labinvest.3780415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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