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Article

VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans.

PloS one - 4 Feb 2010

Fujikawa Keiko, Iwata Takeshi, Inoue Kaoru, Akahori Masakazu, Kadotani Hanako, Fukaya Masahiro, Watanabe Masahiko, Chang Qing, Barnett Edward M, Swat Wojciech

Abstract excerpt

BACKGROUND: Glaucoma is a leading cause of blindness worldwide. Nonetheless, the mechanism of its pathogenesis has not been well-elucidated, particularly at the molecular level, because of insufficient availability of experimental genetic animal models. METHODOLOGY/PRINCIPAL FINDINGS: Here we demonstrate that deficiency of Vav2 and Vav3, guanine nucleotides exchange factors for Rho guanosine triphosphatases,...

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Source

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Identifiers

PMID: 20140222
DOI: 10.1371/journal.pone.0009050
PMCID: PMC2816215

Genes

VAV2
VAV3

Provenance

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