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Article

CRISPR/Cas9-Mediated Mutation of αA-Crystallin Gene Induces Congenital Cataracts in Rabbits.

Investigative ophthalmology & visual science - 1 May 2017

Yuan Lin, Yao Haobin, Xu Yuxin, Chen Mao, Deng Jichao, Song Yuning, Sui Tingting, Wang Yong, Huang Yongye, Li Zhanjun, Lai Liangxue

Abstract excerpt

Purpose: The present study aimed to investigate the role of the αA-crystallin gene in inducing congenital cataracts in rabbits and to construct a novel animal model for characterization and pathologic analysis of congenital cataracts for future research. Methods: We generated αA-crystallin gene knockout rabbits with congenital cataracts by coinjection of Cas9 mRNA and sgRNA into zygotes. Cataract phenotypes were...

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PMID: 28475701
DOI: 10.1167/iovs.16-21287

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