Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3.

doi:10.1167/iovs.05-1208

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Article

Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3.

Investigative ophthalmology & visual science - 1 Aug 2006

Banh Alice, Deschamps Paula A, Gauldie Jack, Overbeek Paul A, Sivak Jacob G, West-Mays Judith A

Abstract excerpt

PURPOSE: Smad3, a mediator of TGF-beta signaling has been shown to be involved in the epithelial-to-mesenchymal transformation (EMT) of lens epithelial cells in a lens injury model. In this study, the role of Smad3 in anterior subcapsular cataract (ASC) formation was investigated in a transgenic TGF-beta/Smad3 knockout mouse model. METHODS: TGF-beta1 transgenic mice (containing a human TGF-beta1 cDNA construct...

Topics

Actins
Animals
Apoptosis
Blotting, Western
Cataract
Collagen Type IV
Fibronectins
Fluorescent Antibody Technique, Indirect
Gene Expression Regulation
Genotype
In Situ Nick-End Labeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lens Capsule, Crystalline

Lens, Crystalline

Mice

Mice, Inbred C57BL

Mice, Knockout

Mice, Transgenic

Smad3 Protein

Source

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Identifiers

PMID: 16877415
DOI: 10.1167/iovs.05-1208
PMCID: PMC2811063

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