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Article

Conditional Knockout of CTGF Affects Corneal Wound Healing

14 Mar 2014

Abstract excerpt

PURPOSE: This study aimed to elucidate the role of connective tissue growth factor (CTGF) in healthy eyes and wounded corneas of mice and rabbits. Conditional knockout mice were used to determine the role of CTGF in corneal healing. METHODS: CTGF expression was determined using transgenic mice carrying CTGF promoter driven-eGFP, quantitative RT-PCR, and immunofluorescent staining. Mice that carried two floxed...

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PMID: 24627144
DOI: 10.1167/iovs.13-12735

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