Article
A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth.
Infection and immunity - 1 Jan 2009
Losick Vicki P, Stephan Kristin, Smirnova Irina I, Isberg Ralph R, Poltorak Alexander
Abstract excerpt
Mouse-derived macrophages have the unique ability to restrict or permit Legionella pneumophila intracellular growth. The common inbred mouse strain C57BL/6J (B6) restricts L. pneumophila growth, whereas macrophages derived from A/J mice allow >10(3)-fold bacterial growth within three days. This phenotypic difference was mapped to the mouse Naip5 allele. The B6 restrictive Naip5 allele is dominant, and six amino...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Chromosome Mapping
- Colony Count, Microbial
- Cytosol
- Genes, Dominant
- Legionella pneumophila
- Macrophages
- Mice