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Article

Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.

Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2010

Siatecka Miroslawa, Sahr Kenneth E, Andersen Sabra G, Mezei Mihaly, Bieker James J, Peters Luanne L

Abstract excerpt

Studies of mouse models of anemia have long provided fundamental insights into red blood cell formation and function. Here we show that the semidominant mouse mutation Nan ("neonatal anemia") carries a single amino acid change (E339D) within the second zinc finger of the erythroid Krüppel-like factor (EKLF), a critical erythroid regulatory transcription factor. The mutation alters the DNA-binding specificity of...

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Identifiers

PMID: 20696915
DOI: 10.1073/pnas.1004996107
PMCID: PMC2930539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.PMID 20696915Read ↗

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Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis.Semantic proximity Read ↗

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The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.Semantic proximity Read ↗

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