Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors.

doi:10.1200/JCO.2002.20.4.1043

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Article

Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Feb 2002

Lindor Noralane M, Burgart Lawrence J, Leontovich Olga, Goldberg Richard M, Cunningham Julie M, Sargent Daniel J, Walsh-Vockley Catherine, Petersen Gloria M, Walsh Michael D, Leggett Barbara A, Young Joanne P, Barker Melissa A, Jass Jeremy R, Hopper John, Gallinger Steve, Bapat Bharati, Redston Mark, Thibodeau Stephen N

Abstract excerpt

PURPOSE: To compare microsatellite instability (MSI) testing with immunohistochemical (IHC) detection of hMLH1 and hMSH2 in colorectal cancer. PATIENTS AND METHODS: Colorectal cancers from 1,144 patients were assessed for DNA mismatch repair deficiency by two methods: MSI testing and IHC detection of hMLH1 and hMSH2 gene products. High-frequency MSI (MSI-H) was defined as more than 30% instability of at least...

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PMID: 11844828
DOI: 10.1200/JCO.2002.20.4.1043

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