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Article

Clinical Relevance of Microsatellite Instability in Colorectal Cancer

2 Jun 2010

Abstract excerpt

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide units in microsatellites. It arises in tumors with deficient mismatch repair due to the inactivation of one of the four mismatch repair genes: MSH2, MLH1, MSH6, and PMS2. In order to determine the MSI status of a tumor, microdissection and polymerase chain reaction-based detection strategies are required. For practical...

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PMID: 20516444
DOI: 10.1200/jco.2009.27.0652

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