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Article

Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer.

Scientific reports - 18 Jun 2021

Dedeurwaerdere Franceska, Claes Kathleen Bm, Van Dorpe Jo, Rottiers Isabelle, Van der Meulen Joni, Breyne Joke, Swaerts Koen, Martens Geert

Abstract excerpt

DNA mismatch repair deficiency (dMMR) testing is crucial for diagnosing Lynch syndrome and detection of microsatellite unstable (MSI) tumors eligible for immunotherapy. The aim of this study was to compare the relative diagnostic performance of three molecular MSI assays: polymerase chain reaction (PCR), MSI testing by Idylla and next-generation-sequencing (NGS) on 49 tumor samples (28 colorectal and 21...

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Source

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Identifiers

PMID: 34145315
DOI: 10.1038/s41598-021-91974-x
PMCID: PMC8213758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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