Article
Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors.
The American journal of surgical pathology - 1 Oct 1999
Marcus V A, Madlensky L, Gryfe R, Kim H, So K, Millar A, Temple L K, Hsieh E, Hiruki T, Narod S, Bapat B V, Gallinger S, Redston M
Abstract excerpt
Inactivation of deoxyribonucleic acid (DNA) mismatch repair genes, most commonly human mutL homologue 1 (hMLH1) or human mutS homologue 2 (hMSH2), is a recently described alternate pathway in cancer development and progression. The resulting genetic instability is characterized by widespread somatic mutations in tumor DNA, and is termed high-frequency microsatellite instability (MSI-H). Although described in a...
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