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Article

Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2004

de Jong Andrea E, van Puijenbroek Marjo, Hendriks Yvonne, Tops Carli, Wijnen Juul, Ausems Margreet G E M, Meijers-Heijboer Hanne, Wagner Anja, van Os Theo A M, Bröcker-Vriends Annette H J T, Vasen Hans F A, Morreau Hans

Abstract excerpt

PURPOSE: Immunohistochemistry (IHC) and microsatellite instability (MSI) analysis can be used to identify patients with a possible DNA mismatch repair defect [hereditary nonpolyposis colorectal carcinoma (HNPCC)]. The Bethesda criteria have been proposed to select families for determination of MSI. The aims of this study were to assess the yield of MSI analysis in families suspected for HNPCC, to compare the...

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Share to Adenosine Triphosphatases
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14871975
DOI: 10.1158/1078-0432.ccr-0956-3

Genes

PMS2
MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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