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Article

Immunohistochemistry for MSH2 and MHL1: a method for identifying mismatch repair deficient colorectal cancer

1 Jun 2001

Abstract excerpt

Colorectal cancers with DNA mismatch repair (MMR) gene mutations characteristically display a high rate of replication errors in simple repetitive sequences detectable as microsatellite instability (MSI). Most are the result of somatic MMR dysfunction; however, a subset are caused by germline mutations. The availability of commercial antibodies for MSH2 and MLH1 [corrected] offers an alternative strategy to...

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PMID: 11376026
DOI: 10.1136/jcp.54.6.484

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Source receipt: pubmed, retrieved 7 Sept 2026.

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