Clinical Uses of Microsatellite Instability Testing in Colorectal Cancer: An Ongoing Challenge

Abstract excerpt

Microsatellite instability (MSI) is the mutational signature found in colorectal cancers (CRCs) that evolve as a result of inactivation of the DNA mismatch repair (MMR) system. MSI can be found in approximately 15% of all CRCs. Approximately 3% of all CRCs are a consequence of Lynch Syndrome, and nearly all Lynch Syndrome CRCs have MSI. 1 Another 12% of CRCs represent the noninherited form of DNA MMR inactivation...