Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer.

doi:10.1200/JCO.2005.04.671

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Article

Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Sept 2005

Southey Melissa C, Jenkins Mark A, Mead Leeanne, Whitty Jonathan, Trivett Melanie, Tesoriero Andrea A, Smith Letitia D, Jennings Kim, Grubb Garry, Royce Simon G, Walsh Michael D, Barker Melissa A, Young Joanne P, Jass Jeremy R, St John D James B, Macrae Finlay A, Giles Graham G, Hopper John L

Abstract excerpt

PURPOSE: The relationships between mismatch repair (MMR) protein expression, microsatellite instability (MSI), family history, and germline MMR gene mutation status have not been studied on a population basis. METHODS: We studied 131 unselected patients with colorectal cancer diagnosed younger than age 45 years. For the 105 available tumors, MLH1, MSH2, MSH6, and PMS2 protein expression using immunohistochemistry...

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Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adenosine Triphosphatases

Share to Base Pair Mismatch

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to DNA Repair Enzymes

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Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

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Identifiers

PMID: 16116158
DOI: 10.1200/JCO.2005.04.671

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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