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Article

The phenomenon known as acquired activated protein C resistance

1 Dec 2001

Abstract excerpt

Resistance to the effect of activated protein C (APC), added to plasma from patients with a history of deep-vein thrombosis, was reported by Amer et al (1990), and the significance of inherited resistance was recognized by Dahlback et al (1993). In the majority of subjects, inherited resistance results from the Leiden mutation (factor V Leiden, FVL) in the gene coding for coagulation factor V (Bertina et al,...

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Share to Blood Coagulation and Thrombosis Mechanisms
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PMID: 11843807
DOI: 10.1046/j.1365-2141.2001.03203.x

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