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Article

Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia.

Haematologica - 1 Jan 2000

De Stefano V, Leone G

Abstract excerpt

Inherited resistance to activated protein C (APC) was recently recognized as a novel cause underlying venous thrombophilia. In most cases APC-resistance is due to a single point mutation in the factor V gene leading to a replacement of Arg506 with Gln (factor V Leiden). Amino acid substitution occurs at one of the APC cleavage sites of factor Va, rendering it resistant to APC inactivation. Plasma anticoagulant...

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Identifiers

PMID: 7590506

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia.PMID 7590506Read ↗

Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.Semantic proximity Read ↗

Resistance to activated protein C caused by the R506Q mutation in the gene for factor V is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Congenital and acquired activated protein C resistance.Semantic proximity Read ↗

Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.Semantic proximity Read ↗

Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C.Semantic proximity Read ↗

Resistance to activated protein C caused by the factor VR506Q mutation is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis.Semantic proximity Read ↗

Factor V Leiden and activated protein C resistance.Semantic proximity Read ↗

Homozygous APC-resistance combined with inherited type I protein S deficiency in a young boy with severe thrombotic disease.Semantic proximity Read ↗

Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein SSemantic proximity Read ↗

APC resistance: biological basis and acquired influences.Semantic proximity Read ↗

Activated protein C resistance: from phenotype to genotype and clinical practice.Semantic proximity Read ↗

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