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Article

Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.

Haemostasis - 1 Jan 2000

Dahlbäck B

Abstract excerpt

Our laboratory recently found a novel mechanism for thrombophilia, which is characterized by an inherited resistance to activated protein C (APC). The APC-resistance test, which measures the anticoagulant response to APC in an activated partial thromboplasin time (APTT) reaction, was devised and used to screen a cohort of consecutive thrombosis patients. APC-resistance was found in approximately 40% of the cases....

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Source

Identifiers

PMID: 7959362
DOI: 10.1159/000217094

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.PMID 7959362Read ↗

Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia.Semantic proximity Read ↗

Congenital and acquired activated protein C resistance.Semantic proximity Read ↗

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Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis.Semantic proximity Read ↗

Factor V Leiden and activated protein C resistance.Semantic proximity Read ↗

Resistance to activated protein C caused by the factor VR506Q mutation is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.Semantic proximity Read ↗

Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein SSemantic proximity Read ↗

Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C.Semantic proximity Read ↗

The phenomenon known as acquired activated protein C resistanceSemantic proximity Read ↗

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