Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.

doi:10.1159/000217094

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Article

Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.

Haemostasis - 1 Jan 2000

Dahlbäck B

Abstract excerpt

Our laboratory recently found a novel mechanism for thrombophilia, which is characterized by an inherited resistance to activated protein C (APC). The APC-resistance test, which measures the anticoagulant response to APC in an activated partial thromboplasin time (APTT) reaction, was devised and...

Topics

Factor V
Genetic Predisposition to Disease
Humans
Mutation
Partial Thromboplastin Time
Pedigree
Protein C
Thrombophlebitis

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