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Article

Congenital and acquired activated protein C resistance.

Seminars in vascular medicine - 1 Feb 2003

Nicolaes Gerry A F, Dahlbäck Björn

Abstract excerpt

Resistance to the anticoagulant action of activated protein C, APC resistance, is a highly prevalent risk factor for venous thrombosis among individuals of Caucasian origin. In most cases, APC resistance is associated with a single missense mutation in the gene for coagulation factor V (FV (Leiden)), which predicts the replacement of Arg (506) with a Gln at one of the cleavage sites for APC in factor V. Factor V...

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Identifiers

PMID: 15199491
DOI: 10.1055/s-2003-38331

Genes

APC

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Source receipt: pubmed, retrieved 7 Sept 2026.

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