Activated protein C resistance: from phenotype to genotype and clinical practice.

doi:10.1016/s0268-960x(95)90011-x

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Article

Activated protein C resistance: from phenotype to genotype and clinical practice.

Blood reviews - 1 Dec 1995

Hillarp A, Dahlbäck B, Zöller B

Abstract excerpt

The anticoagulant protein C system is an important regulator of the blood coagulation process. Its targets are the procoagulant cofactors factor Va and factor VIIIa, which are cleaved and inactivated by activated protein C, protein S and intact factor V working as cofactors. Genetic defects of pr...

Topics

Anticoagulants
Drug Resistance
Genotype
Humans
Mutation
Phenotype
Protein C
Thromboembolism
Thrombosis

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