Article
Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis.
Annual review of medicine - 1 Jan 1997
Zöller B, Hillarp A, Berntorp E, Dahlbäck B
Abstract excerpt
Inherited resistance to activated protein C (APC) was recently discovered to be a cause of familial thrombophilia and is now known to be the most common genetic risk factor for venous thrombosis. It is caused by a single point mutation in the gene for factor V, which predicts substitution or argi...
Topics
- DNA Mutational Analysis
- Factor V
- Genetic Predisposition to Disease
- Genetics, Population
- Humans
- Oligopeptides
- Protein C
- Risk Factors
- Thrombophlebitis