Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis.

Annual review of medicine - 1 Jan 1997

Zöller B, Hillarp A, Berntorp E, Dahlbäck B

Abstract excerpt

Inherited resistance to activated protein C (APC) was recently discovered to be a cause of familial thrombophilia and is now known to be the most common genetic risk factor for venous thrombosis. It is caused by a single point mutation in the gene for factor V, which predicts substitution or arginine (R) at position 506 with a glutamine (Q). Accordingly, the activated form of mutated factor V (FVa:Q506) is more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to Factor V
Share to APC gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetics, Population

Share to Oligopeptides

Share to Protein C

Share to Risk Factors

Source

Identifiers

PMID: 9046944
DOI: 10.1146/annurev.med.48.1.45

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis.PMID 9046944Read ↗

Resistance to activated protein C caused by the factor VR506Q mutation is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Resistance to activated protein C caused by the R506Q mutation in the gene for factor V is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.Semantic proximity Read ↗

Resistance to activated protein C caused by a factor V gene mutation.Semantic proximity Read ↗

Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis.Semantic proximity Read ↗

Congenital and acquired activated protein C resistance.Semantic proximity Read ↗

Activated protein C resistance: from phenotype to genotype and clinical practice.Semantic proximity Read ↗

Activated protein C resistance: the most common risk factor for venous thromboembolism.Semantic proximity Read ↗

New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg506 to Gln mutation in factor V as a pathogenic risk factor for venous thrombosis.Semantic proximity Read ↗

Factor V Leiden and activated protein C resistance.Semantic proximity Read ↗

Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.Semantic proximity Read ↗

Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.