Factor V Leiden and activated protein C resistance.

doi:10.1016/s0065-2423(09)49006-1

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Article

Factor V Leiden and activated protein C resistance.

Advances in clinical chemistry - 1 Jan 2009

Segers Olivier, Castoldi Elisabetta

Abstract excerpt

Activated protein C (APC) proteolytically inactivates factors Va (FVa) and VIIIa (FVIIIa), which in turn control two key steps of the coagulation cascade. The pathophysiological importance of this anticoagulant mechanism is illustrated by the severe prothrombotic diathesis associated with the congenital deficiencies of protein C and its cofactor protein S. A poor anticoagulant response of plasma to APC (APC...

Topics

Activated Protein C Resistance
Factor V
Humans
Mutation

Source

Open in PubMed

Identifiers

PMID: 19947358
DOI: 10.1016/s0065-2423(09)49006-1

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