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Article

Identification of novel proteolytically inactive mutations in coronavirus 3C-like protease using a combined approach.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2019

Zhou Junwei, Fang Liurong, Yang Zhixiang, Xu Shangen, Lv Mengting, Sun Zheng, Chen Jiyao, Wang Dang, Gao Jun, Xiao Shaobo

Abstract excerpt

Coronaviruses (CoVs) infect humans and multiple other animal species, causing highly prevalent and severe diseases. 3C-like proteases (3CLpros) from CoVs (also called main proteases) are essential for viral replication and are also involved in polyprotein cleavage and immune regulation, making them attractive and effective targets for the development of antiviral drugs. Herein, the 3CLpro from the porcine...

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PMID: 31690127
DOI: 10.1096/fj.201901624RR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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