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Human <i>DINB1</i> -encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini

12 Feb 2002

Abstract excerpt

Both in yeast and humans, DNA polymerase (Pol) (eta) functions in the error-free replication of UV-damaged DNA, and Pol(eta) has the unique ability to efficiently replicate through a cis-syn thymine-thymine (T-T) dimer by inserting two As opposite the two Ts of the dimer. Although human DINB1-encoded Pol(kappa) belongs to the same protein family as Pol(eta), Pol(kappa) shows no ability to bypass this DNA lesion...

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PMID: 11842189
DOI: 10.1073/pnas.032594399

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