Article
Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene.
The Journal of biological chemistry - 5 Jan 2001
Gerlach V L, Feaver W J, Fischhaber P L, Friedberg E C
Abstract excerpt
The Escherichia coli dinB gene encodes DNA polymerase (pol) IV, a protein involved in increasing spontaneous mutations in vivo. The protein-coding region of DINB1, the human ortholog of DNA pol IV, was fused to glutathione S-transferase and expressed in insect cells. The purified fusion protein was shown to be a template-directed DNA polymerase that we propose to designate pol kappa. Human pol kappa lacks...
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