Article
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene.
The Journal of biological chemistry - 15 Dec 2000
Ohashi E, Bebenek K, Matsuda T, Feaver W J, Gerlach V L, Friedberg E C, Ohmori H, Kunkel T A
Abstract excerpt
Mammalian DNA polymerase kappa (pol kappa), a member of the UmuC/DinB nucleotidyl transferase superfamily, has been implicated in spontaneous mutagenesis. Here we show that human pol kappa copies undamaged DNA with average single-base substitution and deletion error rates of 7 x 10(-3) and 2 x 10(-3), respectively. These error rates are high when compared to those of most other DNA polymerases. pol kappa also has...
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