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Characterization of Nine Cancer-Associated Variants in Human DNA Polymerase κ.

Chemical research in toxicology - 20 Aug 2018

Antczak Nicole M, Walker Alice R, Stern Hannah R, Leddin Emmett M, Palad Carl, Coulther Timothy A, Swett Rebecca J, Cisneros G Andrés, Beuning Penny J

Abstract excerpt

Specialized DNA damage-bypass Y-family DNA polymerases contribute to cancer prevention by providing cellular tolerance to DNA damage that can lead to mutations and contribute to cancer progression by increasing genomic instability. Y-family polymerases can also bypass DNA adducts caused by chemotherapy agents. One of the four human Y-family DNA polymerases, DNA polymerase (pol) κ, has been shown to be specific...

Topics

Base Pairing
DNA-Directed DNA Polymerase
Humans
Molecular Dynamics Simulation
Neoplasms
Polymorphism, Single Nucleotide
Templates, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30004685
DOI: 10.1021/acs.chemrestox.8b00055
PMCID: PMC6130208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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