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Article

The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymerase kappa.

Biochemistry - 26 May 2009

Niimi Naoko, Sassa Akira, Katafuchi Atsushi, Grúz Petr, Fujimoto Hirofumi, Bonala Radha-Rani, Johnson Francis, Ohta Toshihiro, Nohmi Takehiko

Abstract excerpt

Human DNA is continuously damaged by exogenous and endogenous genotoxic insults. To counteract DNA damage and ensure the completion of DNA replication, cells possess specialized DNA polymerases (Pols) that bypass a variety of DNA lesions. Human DNA polymerase kappa (hPolkappa) is a member of the Y-family of DNA Pols and a direct counterpart of DinB in Escherichia coli. hPolkappa is characterized by its ability to...

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Identifiers

PMID: 19341290
DOI: 10.1021/bi900153t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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