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Article

Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002

Chen Fei, Zhang Zhuo, Bower Jacquelyn, Lu Yongju, Leonard Stephen S, Ding Min, Castranova Vince, Piwnica-Worms Helen, Shi Xianglin

Abstract excerpt

Arsenite is a known human carcinogen that induces tumorigenesis through either a genotoxic or an epigenetic mechanism. In this study, the effect of arsenite on cell cycle regulation and the mechanisms that contribute to this effect were investigated. Treatment of the cells with arsenite suppressed cell proliferation and reduced cell viability in a dose- or time-dependent manner. Analysis of cell cycle profile and...

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Identifiers

PMID: 11842186
DOI: 10.1073/pnas.032428899
PMCID: PMC122307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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