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DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.

Molecular cell - 3 Dec 2004

St Clair Selvon, Giono Luciana, Varmeh-Ziaie Shohreh, Resnick-Silverman Lois, Liu Wen-Jun, Padi Abhilash, Dastidar Jayasri, DaCosta Andrea, Mattia Melissa, Manfredi James J

Abstract excerpt

The Cdc25C phosphatase mediates cellular entry into mitosis. The cdc25C gene is a target for transcriptional downregulation by the tumor suppressor protein p53, and this repression can be shown to contribute to p53-dependent cell cycle arrest. Two independent mechanisms have been identified. One involves the direct binding of p53 to a site in the cdc25C promoter, and the second involves a CDE/CHR element. Both of...

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PMID: 15574328
DOI: 10.1016/j.molcel.2004.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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