Article
Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions.
Developmental biology - 1 Sept 2013
Sarraf-Zadeh Ladan, Christen Stefan, Sauer Uwe, Cognigni Paola, Miguel-Aliaga Irene, Stocker Hugo, Köhler Katja, Hafen Ernst
Abstract excerpt
In Drosophila, growth takes place during the larval stages until the formation of the pupa. Starvation delays pupariation to allow prolonged feeding, ensuring that the animal reaches an appropriate size to form a fertile adult. Pupariation is induced by a peak of the steroid hormone ecdysone produced by the prothoracic gland (PG) after larvae have reached a certain body mass. Local downregulation of the...
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