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Article

Genetic analysis of insulin signaling in Drosophila.

Trends in endocrinology and metabolism: TEM - 1 Jan 2000

Garofalo Robert S

Abstract excerpt

Studies in the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans have revealed that components of the insulin signaling pathway have been highly conserved during evolution. Genetic analysis in Drosophila suggests that structural conservation also extends to the functional level. Flies carrying mutations that reduce insulin signaling have a growth deficiency phenotype similar to that seen...

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PMID: 11943559
DOI: 10.1016/s1043-2760(01)00548-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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