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Article

Characterization of the oligomeric states of the CK2 α2β2 holoenzyme in solution.

The Biochemical journal - 6 Jul 2017

Lolli Graziano, Naressi Denise, Sarno Stefania, Battistutta Roberto

Abstract excerpt

The regulatory mechanism of protein kinase CK2 has still to be fully clarified. The prevailing hypothesis is that CK2 is controlled by a self-polymerisation mechanism leading to inactive supramolecular assemblies that, when needed, can be disassembled into the α2β2 monomer, the active form of the holoenzyme. In vitro, monomeric α2β2 seems present only at high ionic strengths, typically 0.35-0.50 M NaCl, while at...

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Identifiers

PMID: 28572157
DOI: 10.1042/BCJ20170189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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