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Cutting Edge: CD8 T Cell-Mediated Demyelination Is IFN-γ Dependent in Mice Infected with a Neurotropic Coronavirus

1 Feb 2002

Abstract excerpt

Mice infected with the murine coronavirus, mouse hepatitis virus, strain JHM (MHV) develop an immune-mediated demyelinating encephalomyelitis. We showed previously that adoptive transfer of MHV-immune splenocytes depleted of either CD4 or CD8 T cells to infected RAG1(-/-) recipients (mice deficient in recombination activation gene 1) resulted in demyelination. Herein we show that transfer of CD8 T cell-enriched...

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Identifiers

PMID: 11823480
DOI: 10.4049/jimmunol.168.4.1547

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