Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Axonal Damage Is T Cell Mediated and Occurs Concomitantly with Demyelination in Mice Infected with a Neurotropic Coronavirus

1 Jul 2001

Abstract excerpt

Mice infected with mouse hepatitis virus (MHV) strain JHM develop primary demyelination. Herein we show that axonal damage occurred in areas of demyelination and also in adjacent areas devoid of myelin damage. Immunodeficient MHV-infected RAG1-/- mice (mice defective in recombinase activating gene 1 expression) do not develop demyelination unless they receive splenocytes from a mouse previously immunized against...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to Multiple Sclerosis Research Studies
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11390613
DOI: 10.1128/jvi.75.13.6115-6120.2001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Axonal Damage Is T Cell Mediated and Occurs Concomitantly with Demyelination in Mice Infected with a Neurotropic CoronavirusPMID 11390613Read ↗

Cutting Edge: CD8 T Cell-Mediated Demyelination Is IFN-γ Dependent in Mice Infected with a Neurotropic CoronavirusSemantic proximity Read ↗

Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis: When can axonal injury be beneficial?Semantic proximity Read ↗

Role of CTL mutants in demyelination induced by mouse hepatitis virus, strain JHM.Semantic proximity Read ↗

Mouse Hepatitis Virus Infection of the Central Nervous System: Chemokine-Mediated Regulation of Host Defense and DiseaseSemantic proximity Read ↗

Axonal loss in multiple sclerosis: causes and mechanisms.Semantic proximity Read ↗

Demyelination Determinants Map to the Spike Glycoprotein Gene of Coronavirus Mouse Hepatitis VirusSemantic proximity Read ↗

Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM.Semantic proximity Read ↗

Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.Semantic proximity Read ↗

Targeting of IgMkappa antibodies to oligodendrocytes promotes CNS remyelination.Semantic proximity Read ↗

In vivo expression of major histocompatibility complex molecules on oligodendrocytes and neurons during viral infection.Semantic proximity Read ↗

Perforin-dependent neurologic injury in a viral model of multiple sclerosis.Semantic proximity Read ↗

CD8+ T Cells Cause Disability and Axon Loss in a Mouse Model of Multiple SclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.