Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease.

doi:10.1016/s1074-7613(00)80320-9

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Article

Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease.

Immunity - 1 Sept 1996

Pewe L, Wu G F, Barnett E M, Castro R F, Perlman S

Abstract excerpt

C57BI/6 mice infected with mouse hepatitis virus, strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis. Infectious virus can be isolated only from symptomatic mice. In C57BI/6 mice, two CD8+ T cell epitopes within the MHV-JHM surface glycoprotein were previously identified. Here...

Topics

Animals
Base Sequence
Coronavirus Infections
Cytotoxicity, Immunologic
Demyelinating Diseases
Epitopes
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Murine hepatitis virus
Mutation
RNA, Viral
T-Lymphocytes, Cytotoxic

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