Article
Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.
Journal of virology - 1 Oct 1997
Pewe L, Xue S, Perlman S
Abstract excerpt
Under certain conditions, C57BL/6 mice persistently infected with mouse hepatitis virus strain JHM (MHV-JHM) develop clinical disease and histological evidence of demyelination several weeks after inoculation with virus. In a previous report, we showed that mutations in the RNA encoding an immuno...
Topics
- Amino Acid Sequence
- Animals
- Brain
- CD8-Positive T-Lymphocytes
- Coronavirus Infections
- Genetic Variation
- Mice
- Mice, Inbred C57BL
- Mice, SCID
- Murine hepatitis virus
- Mutation
- Point Mutation
- RNA, Viral
- Sequence Deletion
- Species Specificity
- Spinal Cord
- T-Lymphocytes, Cytotoxic
- Time Factors