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Article

Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.

Journal of virology - 1 Oct 1997

Pewe L, Xue S, Perlman S

Abstract excerpt

Under certain conditions, C57BL/6 mice persistently infected with mouse hepatitis virus strain JHM (MHV-JHM) develop clinical disease and histological evidence of demyelination several weeks after inoculation with virus. In a previous report, we showed that mutations in the RNA encoding an immunodominant CD8 T-cell epitope within the surface glycoprotein (epitope S-510-518) were present in all persistently...

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Identifiers

PMID: 9311846
DOI: 10.1128/JVI.71.10.7640-7647.1997
PMCID: PMC192113

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Source receipt: pubmed, retrieved 7 Sept 2026.

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