Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus.

doi:10.1128/JVI.72.7.5912-5918.1998

Back to search

Article

Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus.

Journal of virology - 1 Jul 1998

Pewe L, Xue S, Perlman S

Abstract excerpt

C57BL/6 mice infected with mouse hepatitis virus strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis several weeks after inoculation. Previously, we showed that mutations in the immunodominant CD8 T-cell epitope (S-510-518) could be detected in nearly all samples of RNA and vir...

Topics

Animals
Coronavirus Infections
Encephalomyelitis
Epitopes, T-Lymphocyte
Growth Disorders
Mice
Mice, Inbred BALB C
Murine hepatitis virus
Mutation
T-Lymphocytes, Cytotoxic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.