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The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.

Oncogene - 17 Jan 2002

Okorokov Andrei L, Rubbi Carlos P, Metcalfe Su, Milner Jo

Abstract excerpt

The tumour suppressor protein p53 is localized in the cell nucleus where it serves to initiate cellular responses to a variety of stresses, particularly DNA damage and has the capacity to transactivate stress response genes. An emerging body of evidence indicates that its action is also exerted through direct protein-protein interactions. An approach to understanding p53 function has been to analyse its...

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Identifiers

PMID: 11821948
DOI: 10.1038/sj.onc.1205112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.PMID 11821948Read ↗

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