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Article

Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding.

Journal of molecular biology - 31 May 2002

Rippin Thomas M, Freund Stefan M V, Veprintsev Dmitry B, Fersht Alan R

Abstract excerpt

We present an analysis by NMR of a 58 kDa complex of the core domain of the tumour suppressor p53 with DNA that complements and extends the crystal structure analysis. Binding of specific DNA caused significant chemical shifts of residues on the DNA-binding interface that translated into the beta-sheet of the protein. Binding of non-specific DNA caused weak but qualitatively the same shifts, corresponding to...

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PMID: 12051912
DOI: 10.1016/S0022-2836(02)00326-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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