Article
p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.
Oncogene - 6 Sept 2001
Jiang M, Axe T, Holgate R, Rubbi C P, Okorokov A L, Mee T, Milner J
Abstract excerpt
The tumour suppressor p53 is a multifunctional protein important for the maintenance of genomic integrity. It is able to form molecular complexes with different DNA targets and also with cellular proteins involved in DNA transcription and DNA repair. In mammalian cells the biochemical processing of DNA occurs on a nuclear sub-structure termed the nuclear matrix. Previously Deppert and co-workers have identified...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Cell Cycle
- Cell Line, Transformed
- Cells, Cultured
- DNA Damage
- Gene Deletion
- Humans
- Mice
- Mutation
- Nuclear Matrix