Article
New insights into p53 function from structural studies.
Oncogene - 4 Apr 1996
Arrowsmith C H, Morin P
Abstract excerpt
Recent structural analysis of p53 has greatly enhanced our understanding of the biochemical activities of this protein by presenting us with a detailed picture of the chemical groups in the protein that are involved in protein stability, conformation and functional interactions. The current structures form the basis for the design of potential therapeutics which could, for example, revert a DNA-binding mutant...
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