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Article

Mutant p53: "gain of function" through perturbation of nuclear structure and function?

Journal of cellular biochemistry. Supplement - 1 Jan 2000

Deppert W, Göhler T, Koga H, Kim E

Abstract excerpt

Mutant p53 not simply is an inactivated tumor suppressor, as at least some mutant p53 proteins exhibit oncogenic properties. Mutant p53 thus is the most commonly expressed oncogene in human cancer. Accordingly, the expression of mutant p53 in tumors often correlates with bad prognosis, and expression of mutant p53 in p53-negative tumor cells enhances their transformed phenotype. The molecular basis for this "gain...

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PMID: 11389540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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