Binding of MAR-DNA elements by mutant p53: possible implications for its oncogenic functions.

doi:10.1002/(sici)1097-4644(199608)62:2<172::aid-jcb5>3.0.co;2-p

Back to search

Article

Binding of MAR-DNA elements by mutant p53: possible implications for its oncogenic functions.

Journal of cellular biochemistry - 1 Aug 1996

Deppert W

Abstract excerpt

The tumor suppressor p53 is a multifunctional protein whose main duty is to preserve the integrity of the genome. This function of wild-type p53 as "guardian of the genome" is achieved at different levels, as a cell cycle checkpoint protein, halting the cell cycle upon DNA damage, and via a direc...

Topics

Animals
DNA
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Mutation
Oncogenes
Protein Binding
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.