Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53–Tfam–mitochondrial DNA complex in skeletal muscle

Abstract excerpt

Key points p53 is one of several important proteins that regulate the synthesis and function of mitochondria in muscle, and mice lacking p53 have impaired aerobic capacity. The role of p53 in response to physiological stress such as exercise has not been investigated. We demonstrate that acute exercise induces the translocation of p53 to mitochondria, and promotes a subsequent interaction with mitochondrial...

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