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Article

A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2021

Sun Xun, Dyson H Jane, Wright Peter E

Abstract excerpt

The tumor-suppressor p53 is a critical regulator of the cellular response to DNA damage and is tightly regulated by posttranslational modifications. Thr55 in the AD2 interaction motif of the N-terminal transactivation domain functions as a phosphorylation-dependent regulatory switch that modulates p53 activity. Thr55 is constitutively phosphorylated, becomes dephosphorylated upon DNA damage, and is subsequently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33443163
DOI: 10.1073/pnas.2021456118
PMCID: PMC7817127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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